drugs have a variety of uses, from preventing the body’s rejection of transplanted organs, to treatment of
autoimmune diseases. Calcineurin is a high profile target of many
immunosuppressant drugs, such as Cyclosporine.
While effective, these drugs also come with many toxic side effects
causing dizziness, headaches and even hypertension. Therefore there is a need for a safer, less
toxic, calcineurin inhibitor.
USC researchers have developed a peptide inhibitor of calcineuirn: Captin (calcineurin peptide inhibitor). Captin has shown excellent binding affinity for calcineurin.
Additionally Captin has been effective at inhibiting
phosphatase activity of calcineuirn without exhibiting any toxicity towards T
captin a good candidate for future use in
Maloney, Licensing Associate
USC Stevens Center for Innovation