Available Technologies


Project TitleAccelerated Dynamic Contrast Enhanced Magnetic Resonance Imaging
Track Code2016-144, 2016-170
Short Description
TagsDynamic Contrast Enhanced Magnetic Resonance Imaging, tracer-kinetic modeling, direct reconstruction, constrained reconstruction, Nyquist rate
Posted DateJun 6, 2016 8:26 PM

Market Opportunity

Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) is an imaging technique used most often to evaluate cancer and provide information about tumors or other diseases. Conventional DCE-MRI techniques provide limited resolution and coverage that could result in missing tiny tumors (e.g. 2 mm or smaller) or scattered tumors. Newer DCE-MRI techniques claim to provide better resolution, but they still result in poor image quality and low under sampling rates. Higher under-sampling rates are required for accurate diagnosis and effective treatment. In order to help grow the MRI market, which is projected to be worth $7.19 billion by 2021, this issue must be addressed.

USC Solution

USC researchers have developed a direct reconstruction method – a method that directly reconstructs the tracker-kinetic (TK) parameter maps. This method provides improved image quality and high under-sampling rates (up to 100x) over a large coverage area (e.g. the entire brain). These improvements are achieved by using an efficient gradient-based technique to reconstruct the image. Use of this method could help DCE-MRI become the clinical standard for evaluating tumor progression and treatment response.

Value Proposition

  • Improved ease-of-use
  • High under-sampling rate (up to 100x)
  • Allows for a larger coverage area


  • Medical imaging
  • MRI scanners
  • Oncology

Stage of Development

  • Experimentally validated 
  • Available for exclusive and non-exclusive license

Intellectual Property

Contact Information

Denise McKenzie, Licensing Associate

USC Stevens Center for Innovation

(213) 821-0945



File Name Description
NCD 2016-144 2016-170 - Accelerated Dynamic Contrast Enhanced Magnetic Resonance Imaging.pdf None Download