Available Technologies


Project TitleSNPs in the cachexia pathway predict outcomes in colon cancer
Track Code2016-116
Short DescriptionNone
Tagspharmacodiagnostics, colorectal cancer, diagnostics, biomarkers, oncology, cachexia, snps, precision medicine, personalized medicine
Posted DateAug 28, 2017

Market Opportunity

Colorectal cancers (CRC) are the third leading cause of cancer-related deaths in the United States and account for an $8 billion market. Cancer cachexia is a significant cause of morbidity and mortality and affects the majority of patients with advanced cancer. It commonly affects late-stage CRC patients, leading to substantial and progressive functional impairment. Cachexia itself might be a direct result of malignancy as well as some of the chemotherapeutics used to treat it such as bevacizumab. It is known that genes involved in the cachexia pathway play a critical role in the development and progression of CRC. However, we still have a poor understanding of whether polymorphisms in these genes can predict clinical outcomes in patients treated with bevacizumab.

USC Solution

USC researchers have identified novel, small nucleotide polymorphisms (SNPs) in the cachexia pathway that affect treatment outcomes in colorectal cancer patients. Patient tissue samples screened for certain SNPs had a high correlation with prolonged survival with Irinotecan and Bevacizumab treatment. Detection of these novel biomarkers can be easily achievable via PCR-based assays.

Value Proposition

  • Novel biomarkers for predicting efficacy of existing cancer treatments
  • Opportunity to improve progression free survival in colorectal cancer
  • High correlation of SNP genotype with improved patient outcomes


  • Diagnostic tool for predicting treatment outcomes in colorectal cancers

Stage of Development

  • Validated in samples from two distinct clinical cohort studies
  • Available for exclusive and non-exclusive license

Intellectual Property

Contact Information

Camilo Ansarah-Sobrinho, Licensing Associate

USC Stevens Center for Innovation

(213) 821-6071



File Name Description
NCD 2016-116 - SNPs in the cachexia pathway predict outcomes in colon cancer.pdf None Download